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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70373
Species: Homo sapiens
RGD Object: Gene
Symbol: BAX
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:28819
Term: naringin
Definition: A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
Chemical ID: MESH:C005274
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BAXincreases expressionEXP 6480464CTDnaringin results in increased expression of BAX mRNAPMID:22847135
BAXmultiple interactionsEXP 6480464CTDnaringin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]PMID:28422390
BAXmultiple interactionsISOBax (Mus musculus)6480464CTDCHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of BAX protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BAX protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]PMID:30878453 PMID:35166444 PMID:35179299 PMID:36811345
BAXmultiple interactionsISOBax (Rattus norvegicus)6480464CTD[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of BAX protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]PMID:21945202 PMID:30130594 PMID:36598108
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