Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:28819
Term: naringin
Definition: A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
Chemical ID: MESH:C005274
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7368326480464CTDnaringin inhibits the reaction [EGF protein affects the localization of RELA protein], naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein], naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA], naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein], naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]

PMID:22766066
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.