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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11300
Species: Mus musculus
RGD Object: Gene
Symbol: Slc18a2
Name: solute carrier family 18 (vesicular monoamine), member 2
Acc ID: CHEBI:28790
Term: serotonin
Definition: A primary amino compound that is the 5-hydroxy derivative of tryptamine.
Chemical ID: MESH:D012701
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc18a2affects bindingISOSlc18a2 (Rattus norvegicus)5130957RGDSerotonin binds to Slc8a2 protein 
Slc18a2affects bindingISOSlc18a2 (Rattus norvegicus)6480464CTDSLC18A2 protein binds to SerotoninPMID:9038139
Slc18a2affects bindingISOSLC18A2 (Homo sapiens)6480464CTDSerotonin binds to SLC18A2 proteinPMID:7912402
Slc18a2affects uptakeISOSLC18A2 (Homo sapiens)6480464CTDSLC18A2 gene SNP affects the uptake of SerotoninPMID:15475732
Slc18a2increases transportISOSlc18a2 (Rattus norvegicus)6480464CTDSLC18A2 protein results in increased transport of SerotoninPMID:9038139
Slc18a2increases uptakeISOSlc18a2 (Rattus norvegicus)6480464CTDSLC18A2 protein results in increased uptake of SerotoninPMID:1438304 PMID:18287335
Slc18a2multiple interactionsISOSlc18a2 (Rattus norvegicus)6480464CTDCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Dopamine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Norepinephrine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Reserpine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Serotonin inhibits the reaction [SLC18A2 protein binds to Reserpine]; Serotonin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Tetrabenazine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; tributyltin inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]; Valinomycin promotes the reaction [SLC18A2 protein results in increased uptake of Serotonin]PMID:1438304 PMID:18287335 PMID:9038139
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