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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69218
Species: Mus musculus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2, mitochondrial
Acc ID: CHEBI:28770
Term: norlaudanosoline
Definition: An isoquinolinol that has formula C16H17NO4.
Chemical ID: MESH:D013765
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:692196480464CTD[[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine], [ALDH2 protein affects the abundance of Tetrahydropapaveroline] which affects the susceptibility to Cocaine, [CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline

PMID:20729865
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.