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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731478
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC2A4
Name: solute carrier family 2 member 4
Acc ID: CHEBI:28757
Term: fructose
Definition: A ketohexose that is an isomer of glucose.
Chemical ID: MESH:D005632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC2A4decreases expressionEXP 6480464CTDFructose results in decreased expression of SLC2A4 mRNAPMID:18063403
SLC2A4increases expressionISOSlc2a4 (Rattus norvegicus)6480464CTDFructose results in increased expression of SLC2A4 mRNAPMID:15111496
SLC2A4multiple interactionsISOSlc2a4 (Rattus norvegicus)6480464CTD[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]PMID:30256492
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