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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2810
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hnf4a
Name: hepatocyte nuclear factor 4, alpha
Acc ID: CHEBI:28757
Term: fructose
Definition: A ketohexose that is an isomer of glucose.
Chemical ID: MESH:D005632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hnf4adecreases expressionEXP 6480464CTDFructose results in decreased expression of HNF4A mRNA; Fructose results in decreased expression of HNF4A proteinPMID:18563319 PMID:19196556
Hnf4amultiple interactionsEXP 6480464CTDBerberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]; rosiglitazone inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]PMID:18563319 PMID:19196556
Hnf4adecreases expressionISOHNF4A (Homo sapiens)6480464CTDFructose results in decreased expression of HNF4A mRNAPMID:17992261
Hnf4amultiple interactionsISOHNF4A (Homo sapiens)6480464CTDCerulenin inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]PMID:17992261
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