GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ins1 | increases expression | EXP | | 6480464 | CTD | Fructose results in increased expression of INS1 protein | PMID:26858005 | Ins1 | increases secretion | EXP | | 6480464 | CTD | Fructose results in increased secretion of INS1 protein | PMID:23533474 | Ins1 | multiple interactions | EXP | | 6480464 | CTD | Ethanol inhibits the reaction [Fructose results in increased expression of INS1 protein]; Fructose inhibits the reaction [Ethanol results in increased expression of INS1 protein] | PMID:26858005 | Ins1 | decreases expression | ISO | Ins1 (Rattus norvegicus) | 6480464 | CTD | Fructose results in decreased expression of INS1 protein | PMID:3553468 | Ins1 | increases expression | ISO | Ins1 (Rattus norvegicus) | 6480464 | CTD | Fructose results in increased expression of INS1 mRNA; Fructose results in increased expression of INS1 protein | PMID:15680273 PMID:17587757 PMID:18981581 PMID:19605544 PMID:21704028 PMID:21781943 PMID:23533474 PMID:24704288 PMID:25169908 PMID:25559852 PMID:25882089 PMID:26488877 PMID:31661889 PMID:36049592 | Ins1 | increases secretion | ISO | Ins1 (Rattus norvegicus) | 6480464 | CTD | Fructose results in increased secretion of INS1 protein | PMID:20470786 PMID:22627169 PMID:23533474 PMID:26973390 | Ins1 | multiple interactions | ISO | Ins1 (Rattus norvegicus) | 6480464 | CTD | 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [chrysin inhibits the reaction [Fructose results in increased expression of INS1 protein]]; [dapagliflozin co-treated with Atorvastatin] inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein]; [Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein; [Dietary Fats co-treated with Fructose] results in increased secretion of INS1 protein; [Fructose co-treated with Dietary Fats] results in increased expression of INS1 protein; [Fructose co-treated with Propylthiouracil] results in increased expression of INS1 protein; [Streptozocin co-treated with Fructose] results in increased expression of INS1 protein; Acetates inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of INS1 protein]; Acetylcysteine inhibits the reaction [Fructose results in increased expression of INS1 protein]; Allopurinol inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of INS1 protein]; Allopurinol inhibits the reaction [Fructose results in increased expression of INS1 protein]; betanin inhibits the reaction [Fructose results in increased expression of INS1 protein]; Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased secretion of INS1 protein]; caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein]; chrysin inhibits the reaction [Fructose results in increased expression of INS1 protein]; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein]; Fatty Acids, Omega-3 inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased secretion of INS1 protein]; Fenofibrate inhibits the reaction [Fructose results in increased secretion of INS1 protein]; Fructose promotes the reaction [bisphenol A results in increased expression of INS1 protein]; Genistein inhibits the reaction [Fructose results in increased expression of INS1 protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of INS1 protein]]; Luteolin inhibits the reaction [Fructose results in increased expression of INS1 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased secretion of INS1 protein]; Metformin inhibits the reaction [Fructose results in increased secretion of INS1 protein]; Oleanolic Acid inhibits the reaction [Fructose results in increased expression of INS1 protein]; Quercetin inhibits the reaction [Fructose results in increased expression of INS1 mRNA]; Quercetin inhibits the reaction [Fructose results in increased expression of INS1 protein]; Quercetin inhibits the reaction [Fructose results in increased secretion of INS1 protein]; Resveratrol inhibits the reaction [Fructose results in increased expression of INS1 protein]; royal jelly inhibits the reaction [Fructose results in increased expression of INS1 protein]; Rutin inhibits the reaction [Fructose results in increased expression of INS1 protein] | PMID:15680273 PMID:18981581 PMID:19605544 PMID:21704028 PMID:22426011 PMID:22627169 PMID:23533474 PMID:24704288 PMID:25169908 PMID:25559852 PMID:25882089 PMID:26488877 PMID:26973390 PMID:30256492 PMID:30343038 PMID:31661889 PMID:32259528 PMID:34656705 PMID:34939712 | | ||||||||||||||||||||||
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