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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737448
Species: Mus musculus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDDoxorubicin results in decreased activity of CAT proteinPMID:24799355 PMID:29775573 PMID:35667395 PMID:37499777
Catdecreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of CAT mRNA; Doxorubicin results in decreased expression of CAT proteinPMID:34713381 PMID:36811345 PMID:37499777
Catincreases activityEXP 6480464CTDDoxorubicin results in increased activity of CAT proteinPMID:11530832 PMID:18503759 PMID:19429816 PMID:21920376 PMID:29061315 PMID:29481770 PMID:6306200
Catincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of CAT mRNA; Doxorubicin results in increased expression of CAT proteinPMID:21463615 PMID:21920376
Catmultiple interactionsEXP 6480464CTDCYP2J2 protein inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; FNDC5 protein inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; indole-3-carbinol inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Luteolin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Meloxicam inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; MT1 affects the reaction [Doxorubicin results in increased expression of CAT protein]; MT2 affects the reaction [Doxorubicin results in increased expression of CAT protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Silymarin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of CAT mRNA]; SIRT6 gene mutant form promotes the reaction [Doxorubicin results in increased expression of CAT protein]PMID:11530832 PMID:18503759 PMID:19429816 PMID:21463615 PMID:24799355 PMID:29481770 PMID:29775573 PMID:34713381 PMID:36811345 PMID:37499777
Cataffects activityISOCat (Rattus norvegicus)6480464CTDDoxorubicin affects the activity of CAT proteinPMID:16325981
Cataffects response to substanceISOCAT (Homo sapiens)6480464CTDCAT protein affects the susceptibility to DoxorubicinPMID:16217747
Catdecreases activityISOCat (Rattus norvegicus)6480464CTDDoxorubicin results in decreased activity of CAT proteinPMID:10755708 PMID:11014987 PMID:14687418 PMID:15369732 PMID:16889571 PMID:17102822 PMID:17582587 PMID:18807757 PMID:19169920 PMID:20146931 PMID:22155320 PMID:25411067 PMID:26825964 PMID:27565713 PMID:29315967 PMID:29913208 PMID:30636491 PMID:30836069 PMID:30928397 PMID:31100273 PMID:31830546 PMID:33484087 PMID:34427160 PMID:34605098 PMID:35987278
Catdecreases activityISOCAT (Homo sapiens)6480464CTDDoxorubicin results in decreased activity of CAT proteinPMID:33331091
Catdecreases expressionISOCat (Rattus norvegicus)6480464CTDDoxorubicin results in decreased expression of CAT mRNA; Doxorubicin results in decreased expression of CAT proteinPMID:11014987 PMID:19767888 PMID:22287321 PMID:22666520 PMID:31376360 PMID:32691977 PMID:33704910 PMID:34713381 PMID:35987278 PMID:37499777
Catincreases activityISOCat (Rattus norvegicus)6480464CTDDoxorubicin results in increased activity of CAT proteinPMID:14745846 PMID:20556922 PMID:9647462
Catincreases expressionISOCat (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of CAT mRNA; Doxorubicin results in increased expression of CAT proteinPMID:10959798 PMID:18845130
Catincreases expressionISOCAT (Homo sapiens)6480464CTDDoxorubicin results in increased expression of CAT mRNA; Doxorubicin results in increased expression of CAT proteinPMID:29803840 PMID:8317554
Catmultiple interactionsISOCat (Rattus norvegicus)6480464CTDcaffeic acid phenethyl ester inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; caffeic acid phenethyl ester promotes the reaction [Doxorubicin results in increased activity of CAT protein]; Carnitine inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; caryophyllene inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Catechin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Chitosan analog inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; corilagin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Doxorubicin affects the expression of and affects the activity of CAT protein; Doxorubicin results in decreased expression of and results in decreased activity of CAT protein; epigallocatechin gallate affects the reaction [Doxorubicin affects the expression of and affects the activity of CAT protein]; FNDC5 protein modified form inhibits the reaction [Doxorubicin results in decreased expression of and results in decreased activity of CAT protein]; FNDC5 protein modified form inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]; Grape Seed Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; iodopravadoline inhibits the reaction [caryophyllene inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]]; kaempferol inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Lycopene affects the reaction [Doxorubicin affects the activity of CAT protein]; Melatonin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Metformin inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]; morin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; NFE2L2 protein promotes the reaction [FNDC5 protein modified form inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]]; Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; pimagedine inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Plant Preparations inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; plumbagin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; Poly(ADP-ribose) Polymerase Inhibitors inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Proanthocyanidins inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; sesamin inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]; SIRT6 protein inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; Tannic Acid inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Trimetazidine inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]PMID:10755708 PMID:14745846 PMID:15369732 PMID:16325981 PMID:16889571 PMID:18807757 PMID:19767888 PMID:20146931 PMID:20556922 PMID:20666448 PMID:22155320 PMID:22287321 PMID:22666520 PMID:25411067 PMID:26825964 PMID:29315967 PMID:29913208 PMID:30636491 PMID:30836069 PMID:30928397 PMID:31100273 PMID:31376360 PMID:32691977 PMID:33484087 PMID:33704910 PMID:34427160 PMID:34605098 PMID:34713381 PMID:35987278 PMID:37499777
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTDIL1A protein promotes the reaction [Doxorubicin results in increased expression of CAT protein]; IL1B protein promotes the reaction [Doxorubicin results in increased expression of CAT protein]; TNF protein promotes the reaction [Doxorubicin results in increased expression of CAT protein]PMID:8317554
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