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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737288
Species: Homo sapiens
RGD Object: Gene
Symbol: TNFRSF1A
Name: TNF receptor superfamily member 1A
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFRSF1Aincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of TNFRSF1A mRNAPMID:29803840
TNFRSF1Aaffects localizationISOTnfrsf1a (Mus musculus)6480464CTDDoxorubicin affects the localization of TNFRSF1A proteinPMID:21097524
TNFRSF1Aaffects response to substanceISOTnfrsf1a (Mus musculus)6480464CTDTNFRSF1A protein affects the susceptibility to DoxorubicinPMID:16618758
TNFRSF1Aincreases expressionISOTnfrsf1a (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of TNFRSF1A proteinPMID:17651020
TNFRSF1Aincreases expressionISOTnfrsf1a (Mus musculus)6480464CTDDoxorubicin results in increased expression of TNFRSF1A mRNA; Doxorubicin results in increased expression of TNFRSF1A proteinPMID:21097524
TNFRSF1Amultiple interactionsISOTnfrsf1a (Mus musculus)6480464CTDTNFRSF1A protein affects the reaction [Doxorubicin affects the expression of PLCD1 mRNA]; TNFRSF1A protein affects the reaction [Doxorubicin affects the expression of PLCD1 protein]; TNFRSF1A protein affects the reaction [Doxorubicin results in decreased expression of FAS protein]PMID:16505099 PMID:16618758
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