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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737272
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC2A1
Name: solute carrier family 2 member 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC2A1decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of SLC2A1 mRNAPMID:22908232
SLC2A1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of SLC2A1 mRNAPMID:16595493 PMID:29803840
SLC2A1decreases expressionISOSlc2a1 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of SLC2A1 mRNAPMID:34296331
SLC2A1multiple interactionsISOSlc2a1 (Mus musculus)6480464CTD[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of SLC2A1 mRNA; corosolic acid inhibits the reaction [Doxorubicin results in decreased expression of SLC2A1 mRNA]PMID:21040762 PMID:34296331
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