GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | FOXO1 | increases phosphorylation | EXP | | 6480464 | CTD | Doxorubicin results in increased phosphorylation of FOXO1 protein | PMID:17935137 | FOXO1 | multiple interactions | EXP | | 6480464 | CTD | wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein] | PMID:17935137 | FOXO1 | affects response to substance | ISO | Foxo1 (Rattus norvegicus) | 6480464 | CTD | FOXO1 protein affects the susceptibility to Doxorubicin | PMID:32075913 | FOXO1 | increases acetylation | ISO | Foxo1 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased acetylation of FOXO1 protein | PMID:25665036 | FOXO1 | increases expression | ISO | Foxo1 (Rattus norvegicus) | 6480464 | CTD | Doxorubicin results in increased expression of FOXO1 mRNA | PMID:35987278 | FOXO1 | increases expression | ISO | Foxo1 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of FOXO1 mRNA | PMID:28329872 | FOXO1 | increases phosphorylation | ISO | Foxo1 (Rattus norvegicus) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of FOXO1 protein | PMID:32075913 | FOXO1 | increases phosphorylation | ISO | Foxo1 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of FOXO1 protein | PMID:32075913 | FOXO1 | multiple interactions | ISO | Foxo1 (Rattus norvegicus) | 6480464 | CTD | 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]; [FOXO1 protein affects the susceptibility to Doxorubicin] which affects the expression of BCL2L11 mRNA; Doxorubicin promotes the reaction [CDK2 protein binds to FOXO1 protein modified form]; FOXO1 protein affects the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; FOXO1 protein affects the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Roscovitine inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]; Tannic Acid inhibits the reaction [Doxorubicin results in increased expression of FOXO1 mRNA] | PMID:32075913 PMID:35987278 | FOXO1 | multiple interactions | ISO | Foxo1 (Mus musculus) | 6480464 | CTD | 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]]; Doxorubicin promotes the reaction [CDK2 protein binds to FOXO1 protein]; Resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]; sirtinol inhibits the reaction [Resveratrol inhibits the reaction [Doxorubicin results in increased acetylation of FOXO1 protein]] | PMID:25665036 PMID:32075913 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |