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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736610
Species: Mus musculus
RGD Object: Gene
Symbol: Akr1b1
Name: aldo-keto reductase family 1 member B
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1b1increases expressionISOAkr1b1 (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of AKR1B1 proteinPMID:37257577
Akr1b1increases expressionISOAKR1B1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of AKR1B1 mRNAPMID:29803840
Akr1b1multiple interactionsISOAKR1B1 (Homo sapiens)6480464CTDAKR1B1 protein results in increased abundance of and results in increased susceptibility to DoxorubicinPMID:37257577
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