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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736182
Species: Homo sapiens
RGD Object: Gene
Symbol: PYGB
Name: glycogen phosphorylase B
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PYGBincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of PYGB mRNAPMID:29803840
PYGBdecreases expressionISOPygb (Mus musculus)6480464CTDDoxorubicin results in decreased expression of PYGB proteinPMID:21251210
PYGBincreases expressionISOPygb (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of PYGB proteinPMID:32691977
PYGBmultiple interactionsISOPygb (Rattus norvegicus)6480464CTDplumbagin inhibits the reaction [Doxorubicin results in increased expression of PYGB protein]PMID:32691977
PYGBmultiple interactionsISOPygb (Mus musculus)6480464CTDsodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of PYGB protein]PMID:21251210
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