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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736050
Species: Mus musculus
RGD Object: Gene
Symbol: Gpx4
Name: glutathione peroxidase 4
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of GPX4 protein

PMID:18037988
multiple interactionsEXP 6480464CTDCarbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]

PMID:18037988
increases expressionISORGD:7360496480464CTDDoxorubicin results in increased expression of GPX4 mRNA

PMID:29803840
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.