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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733814
Species: Mus musculus
RGD Object: Gene
Symbol: Bnip3
Name: BCL2/adenovirus E1B interacting protein 3
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDoxorubicin results in increased expression of BNIP3 mRNA

PMID:19001878, PMID:25896364
multiple interactionsEXP 6480464CTDPARP1 protein promotes the reaction [Doxorubicin results in increased expression of BNIP3 mRNA]

PMID:19001878
decreases expressionISORGD:13509136480464CTDDoxorubicin results in decreased expression of BNIP3 mRNA

PMID:22908232
increases expressionISORGD:13509136480464CTDDoxorubicin results in increased expression of BNIP3 mRNA

PMID:29803840
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.