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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733294
Species: Mus musculus
RGD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apaf1increases expressionISOApaf1 (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of APAF1 proteinPMID:22015447 PMID:25169008
Apaf1increases expressionISOAPAF1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of APAF1 mRNA; Doxorubicin results in increased expression of APAF1 proteinPMID:15939500 PMID:16001973 PMID:34783124 PMID:37406984
Apaf1multiple interactionsISOApaf1 (Rattus norvegicus)6480464CTDPropofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein]PMID:22015447
Apaf1multiple interactionsISOAPAF1 (Homo sapiens)6480464CTDginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA]; NORAD inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein]; pluronic block copolymer p85 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA]PMID:15939500 PMID:34783124 PMID:37406984
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