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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732751
Species: Homo sapiens
RGD Object: Gene
Symbol: NR4A1
Name: nuclear receptor subfamily 4 group A member 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR4A1affects expressionEXP 6480464CTDDoxorubicin affects the expression of NR4A1 mRNAPMID:15205334
NR4A1decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of NR4A1 mRNAPMID:29803840
NR4A1decreases response to substanceEXP 6480464CTDNR4A1 mRNA results in decreased susceptibility to DoxorubicinPMID:16322897
NR4A1increases expressionISONr4a1 (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of NR4A1 mRNAPMID:32289291
NR4A1increases expressionISONr4a1 (Mus musculus)6480464CTDDoxorubicin results in increased expression of NR4A1 mRNAPMID:21040762
NR4A1multiple interactionsISONr4a1 (Mus musculus)6480464CTD[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of NR4A1 mRNAPMID:21040762
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