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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731640
Species: Homo sapiens
RGD Object: Gene
Symbol: ATP2A1
Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ATP2A1affects activityISOAtp2a1 (Rattus norvegicus)6480464CTDDoxorubicin affects the activity of ATP2A1 proteinPMID:15937726
ATP2A1decreases expressionISOAtp2a1 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of ATP2A1 mRNAPMID:36227756
ATP2A1multiple interactionsISOAtp2a1 (Rattus norvegicus)6480464CTDTamoxifen inhibits the reaction [Doxorubicin affects the activity of ATP2A1 protein]PMID:15937726
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