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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731384
Species: Homo sapiens
RGD Object: Gene
Symbol: GATA1
Name: GATA binding protein 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GATA1increases activityEXP 6480464CTDDoxorubicin analog results in increased activity of GATA1 protein; Doxorubicin results in increased activity of GATA1 proteinPMID:14623254 PMID:17097070
GATA1increases expressionEXP 6480464CTDDoxorubicin analog results in increased expression of GATA1 mRNA; Doxorubicin results in increased expression of GATA1 mRNAPMID:17097070
GATA1multiple interactionsEXP 6480464CTDDoxorubicin promotes the reaction [GATA1 protein binds to GSTP1 promoter]PMID:14623254
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