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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fabp3
Name: fatty acid binding protein 3
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fabp3decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of FABP3 mRNAPMID:20470772
Fabp3increases expressionEXP 6480464CTDDoxorubicin results in increased expression of FABP3 proteinPMID:32691977 PMID:34369273
Fabp3increases oxidationEXP 6480464CTDDoxorubicin results in increased oxidation of FABP3 proteinPMID:28818578
Fabp3multiple interactionsEXP 6480464CTDCarnitine inhibits the reaction [Doxorubicin results in decreased expression of FABP3 mRNA]; corilagin inhibits the reaction [Doxorubicin results in increased expression of FABP3 protein]; plumbagin inhibits the reaction [Doxorubicin results in increased expression of FABP3 protein]PMID:20470772 PMID:32691977 PMID:34369273
Fabp3affects expressionISOFABP3 (Homo sapiens)6480464CTDDoxorubicin affects the expression of FABP3 mRNAPMID:29803840
Fabp3increases expressionISOFabp3 (Mus musculus)6480464CTDDoxorubicin results in increased expression of FABP3 proteinPMID:21251210
Fabp3multiple interactionsISOFabp3 (Mus musculus)6480464CTD[Doxorubicin co-treated with MT2A protein] results in increased expression of FABP3 protein; sodium nitrate inhibits the reaction [Doxorubicin results in increased expression of FABP3 protein]PMID:16144979 PMID:21251210
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