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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDDoxorubicin affects the expression of CCND1 mRNA

PMID:12187937
increases expressionEXP 6480464CTDDoxorubicin results in increased expression of CCND1 mRNA

PMID:30261314
decreases expressionISORGD:685566480464CTDDoxorubicin results in decreased expression of CCND1 protein

PMID:16036217, PMID:20826841, PMID:25124555, PMID:27806920
increases degradationISORGD:685566480464CTDDoxorubicin results in increased degradation of CCND1 protein

PMID:22751436
increases expressionISORGD:685566480464CTDDoxorubicin results in increased expression of CCND1 mRNA

PMID:29803840
multiple interactionsISORGD:685566480464CTD2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3, 2-d)pyrimidine promotes the reaction [Doxorubicin results in decreased expression of CCND1 protein], [Estradiol results in increased expression of CCND1 mRNA] which results in increased susceptibility to Doxorubicin, Doxorubicin inhibits the reaction [palbociclib results in increased expression of CCND1 protein], Doxorubicin promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3, 2-d)pyrimidine results in decreased expression of CCND1 protein]

PMID:20826841, PMID:22751436, PMID:28323900
multiple interactionsISORGD:685576480464CTD[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCND1 protein, Doxorubicin promotes the reaction [AZD 6244 results in decreased expression of and results in decreased phosphorylation of CCND1 protein]

PMID:17876044, PMID:19789217
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.