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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDDoxorubicin results in increased cleavage of and results in increased activity of CASP12 protein, pifithrin inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP12 protein]

PMID:15556633, PMID:16687611
increases activityISORGD:7314426480464CTDDoxorubicin results in increased activity of CASP12 protein

PMID:20656019
increases expressionISORGD:7314426480464CTDDoxorubicin results in increased expression of CASP12 mRNA

PMID:26873546
multiple interactionsISORGD:7314426480464CTD[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of CASP12 mRNA

PMID:26873546
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.