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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621622
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tmsb4x
Name: thymosin beta 4, X-linked
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tmsb4xdecreases response to substanceISOTMSB4X (Homo sapiens)6480464CTDTMSB4X protein results in decreased susceptibility to DoxorubicinPMID:16364925
Tmsb4xincreases expressionISOTMSB4X (Homo sapiens)6480464CTDDoxorubicin results in increased expression of TMSB4X mRNAPMID:29803840
Tmsb4xmultiple interactionsISOTMSB4X (Homo sapiens)6480464CTDTMSB4X protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; TMSB4X protein inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP9 protein]PMID:16364925
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