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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDoxorubicin results in increased expression of CCN2 protein

PMID:27087047
multiple interactionsEXP 6480464CTDcoenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein]

PMID:27087047
affects expressionISORGD:7310136480464CTDDoxorubicin affects the expression of CCN2 mRNA

PMID:15205334
affects expressionISORGD:7310146480464CTDDoxorubicin affects the expression of CCN2 mRNA

PMID:15033991
increases expressionISORGD:7310136480464CTDDoxorubicin results in increased expression of CCN2 mRNA

PMID:16579640, PMID:28940058, PMID:29803840, PMID:30031762
increases expressionISORGD:7310146480464CTDDoxorubicin results in increased expression of CCN2 mRNA

PMID:22712078, PMID:28710503
multiple interactionsISORGD:7310146480464CTDLovastatin inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA], NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA]

PMID:22712078, PMID:28710503
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.