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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a2
Name: collagen type I alpha 2 chain
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7309846480464CTDDoxorubicin results in decreased expression of COL1A2 mRNA

PMID:29803840
increases expressionISORGD:7309856480464CTDDoxorubicin results in increased expression of COL1A2 mRNA

PMID:15033991
increases response to substanceISORGD:7309846480464CTDCOL1A2 mRNA results in increased susceptibility to Doxorubicin

PMID:25199881
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.