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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of COL1A1 mRNA; Doxorubicin results in increased expression of COL1A1 proteinPMID:15033991 PMID:29064158 PMID:36764612 PMID:37030624
Col1a1multiple interactionsEXP 6480464CTD2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside inhibits the reaction [Doxorubicin results in increased expression of COL1A1 mRNA]; [[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of COL1A1 mRNA; GSK2795039 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein]; SIRT1 protein affects the reaction [Doxorubicin results in increased expression of COL1A1 protein]; SRT1720 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein]PMID:21040762 PMID:29064158 PMID:36764612 PMID:37030624
Col1a1decreases expressionISOCOL1A1 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of COL1A1 mRNAPMID:29803840
Col1a1increases expressionISOCol1a1 (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of COL1A1 mRNA; Doxorubicin results in increased expression of COL1A1 proteinPMID:27087047 PMID:30588110 PMID:37030624
Col1a1multiple interactionsISOCol1a1 (Rattus norvegicus)6480464CTDcelastrol inhibits the reaction [Doxorubicin results in increased expression of COL1A1 mRNA]; coenzyme Q10 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein]; SRT1720 inhibits the reaction [Doxorubicin results in increased expression of COL1A1 protein]PMID:27087047 PMID:30588110 PMID:37030624
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