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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61989
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ankrd1
Name: ankyrin repeat domain 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ankrd1affects localizationEXP 6480464CTDDoxorubicin affects the localization of ANKRD1 proteinPMID:22532871
Ankrd1decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of ANKRD1 mRNA; Doxorubicin results in decreased expression of ANKRD1 proteinPMID:22532871 PMID:9278441
Ankrd1decreases expressionISOAnkrd1 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of ANKRD1 mRNAPMID:17531194
Ankrd1increases expressionISOANKRD1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of ANKRD1 mRNAPMID:29803840
Ankrd1increases expressionISOAnkrd1 (Mus musculus)6480464CTDDoxorubicin results in increased expression of ANKRD1 mRNA; Doxorubicin results in increased expression of ANKRD1 proteinPMID:16243910 PMID:19429816 PMID:36227756
Ankrd1multiple interactionsISOAnkrd1 (Mus musculus)6480464CTDCYP2J2 protein inhibits the reaction [Doxorubicin results in increased activity of ANKRD1 protein]PMID:19429816
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