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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3752
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spp1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spp1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of SPP1 mRNA; Doxorubicin results in increased expression of SPP1 proteinPMID:11972865 PMID:20211217 PMID:23558518
Spp1decreases expressionISOSpp1 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of SPP1 mRNAPMID:17888722
Spp1decreases expressionISOSPP1 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of SPP1 mRNAPMID:29803840
Spp1increases expressionISOSpp1 (Mus musculus)6480464CTDDoxorubicin results in increased expression of SPP1 mRNAPMID:15033991 PMID:22016648
Spp1multiple interactionsISOSpp1 (Mus musculus)6480464CTDDMD protein affects the reaction [Doxorubicin results in decreased expression of SPP1 mRNA]PMID:17888722
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