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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3increases expressionEXP 6480464CTDDoxorubicin results in increased expression of NOS3 proteinPMID:30142312
Nos3multiple interactionsEXP 6480464CTDerucic acid promotes the reaction [Doxorubicin results in increased expression of NOS3 protein]PMID:30142312
Nos3affects response to substanceISONos3 (Mus musculus)6480464CTDNOS3 protein affects the susceptibility to DoxorubicinPMID:17638931
Nos3decreases expressionISONos3 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of NOS3 mRNA; Doxorubicin results in decreased expression of NOS3 proteinPMID:31158416 PMID:37409694
Nos3decreases phosphorylationISONOS3 (Homo sapiens)6480464CTDDoxorubicin results in decreased phosphorylation of NOS3 proteinPMID:31066085
Nos3decreases response to substanceISONos3 (Mus musculus)6480464CTDNOS3 protein results in decreased susceptibility to DoxorubicinPMID:12591762
Nos3increases response to substanceISONos3 (Mus musculus)6480464CTDNOS3 protein results in increased susceptibility to DoxorubicinPMID:19308358
Nos3multiple interactionsISONos3 (Mus musculus)6480464CTDBDKRB1 protein affects the reaction [Doxorubicin results in decreased expression of NOS3 protein]; BDKRB2 protein affects the reaction [Doxorubicin results in decreased expression of NOS3 protein]; Doxorubicin results in decreased phosphorylation of and results in increased glutathionylation of NOS3 protein; Folic Acid inhibits the reaction [Doxorubicin results in decreased phosphorylation of and results in increased glutathionylation of NOS3 protein]; NOS3 protein affects the reaction [Doxorubicin results in increased abundance of Reactive Oxygen Species]PMID:17638931 PMID:28608983 PMID:37409694
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTDCarvedilol inhibits the reaction [Doxorubicin results in decreased phosphorylation of NOS3 protein]PMID:31066085
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