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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2665
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gata4
Name: GATA binding protein 4
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gata4decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of GATA4 proteinPMID:15767673 PMID:22532871 PMID:32185414
Gata4decreases response to substanceEXP 6480464CTDGATA4 protein results in decreased susceptibility to DoxorubicinPMID:22532871
Gata4decreases activityISOGata4 (Mus musculus)6480464CTDDoxorubicin results in decreased activity of GATA4 proteinPMID:18037988
Gata4decreases expressionISOGATA4 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of GATA4 mRNAPMID:29803840
Gata4decreases expressionISOGata4 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of GATA4 mRNA; Doxorubicin results in decreased expression of GATA4 proteinPMID:16109756 PMID:16449733 PMID:17334414 PMID:17974986 PMID:18083897 PMID:18321777 PMID:20543097 PMID:35979984
Gata4multiple interactionsISOGata4 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [HGF protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]]; bosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 mRNA]; bosentan inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]; Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased activity of GATA4 protein]; CSF3 protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]; EPO protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]; HGF protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]; Tadalafil inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein]; TLR4 protein affects the reaction [Doxorubicin results in decreased expression of GATA4 protein]PMID:16109756 PMID:16449733 PMID:17334414 PMID:17974986 PMID:18037988 PMID:18083897 PMID:18321777 PMID:20543097
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