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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2635
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fth1
Name: ferritin heavy chain 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fth1decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of FTH1 proteinPMID:36195186
Fth1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of FTH1 mRNA; Doxorubicin results in increased expression of FTH1 proteinPMID:18845130
Fth1decreases expressionISOFth1 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of FTH1 proteinPMID:21251210 PMID:36195186
Fth1increases expressionISOFth1 (Mus musculus)6480464CTDDoxorubicin results in increased expression of FTH1 mRNA; Doxorubicin results in increased expression of FTH1 proteinPMID:16243910 PMID:16770644 PMID:20980392
Fth1increases expressionISOFTH1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of FTH1 mRNAPMID:29803840
Fth1multiple interactionsISOFth1 (Mus musculus)6480464CTDHIPK2 protein promotes the reaction [Doxorubicin results in increased expression of FTH1 mRNA]; sodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of FTH1 protein]PMID:20980392 PMID:21251210
Fth1multiple interactionsISOFTH1 (Homo sapiens)6480464CTD[MIR200B results in decreased expression of FTH1 protein] which results in increased susceptibility to DoxorubicinPMID:20390345
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