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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2426
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Csf3
Name: colony stimulating factor 3
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceEXP 6480464CTDCSF3 protein results in decreased susceptibility to Doxorubicin

PMID:16761189
multiple interactionsEXP 6480464CTDCSF3 protein inhibits the reaction [Doxorubicin results in increased expression of FAS protein]

PMID:16761189
decreases expressionISORGD:13509556480464CTDDoxorubicin results in decreased expression of CSF3 mRNA

PMID:29803840
multiple interactionsISORGD:7314166480464CTDCSF3 protein inhibits the reaction [Doxorubicin results in decreased expression of CSF3R protein], CSF3 protein inhibits the reaction [Doxorubicin results in decreased expression of DES protein], CSF3 protein inhibits the reaction [Doxorubicin results in decreased expression of GATA4 protein], CSF3 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein], CSF3 protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein], CSF3 protein inhibits the reaction [Doxorubicin results in increased expression of PTGS2 protein]

PMID:17334414
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.