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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2358
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ckm
Name: creatine kinase, M-type
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ckmdecreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of CKM mRNA; Doxorubicin results in decreased expression of CKM proteinPMID:15764680 PMID:9689591
Ckmincreases activityEXP 6480464CTDDoxorubicin results in increased activity of CKM proteinPMID:34343525
Ckmmultiple interactionsEXP 6480464CTDcelastrol inhibits the reaction [Doxorubicin results in increased secretion of [CKM protein binds to CKB protein]]; Curcumin inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]; Doxorubicin results in increased expression of [CKM protein binds to CKB protein]; Doxorubicin results in increased secretion of [CKM protein binds to CKB protein]; geraniol inhibits the reaction [Doxorubicin results in increased activity of CKM protein]; Proanthocyanidins inhibits the reaction [Doxorubicin results in increased expression of [CKM protein binds to CKB protein]]PMID:29315967 PMID:30588110 PMID:33484087 PMID:34343525
Ckmdecreases expressionISOCKM (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of CKM mRNAPMID:26537877 PMID:28940058 PMID:29803840 PMID:30031762
Ckmincreases expressionISOCkm (Mus musculus)6480464CTDDoxorubicin results in increased expression of CKM proteinPMID:16242529
Ckmmultiple interactionsISOCkm (Mus musculus)6480464CTD[docetaxel co-treated with Doxorubicin] results in increased expression of CKM protein; tetrathiomolybdate inhibits the reaction [Doxorubicin results in increased expression of CKM protein]PMID:16242529 PMID:20457137
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