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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2065
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Afp
Name: alpha-fetoprotein
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Afpmultiple interactionsEXP 6480464CTDchloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]; Doxorubicin inhibits the reaction [Thioacetamide results in increased expression of AFP protein]; Doxorubicin promotes the reaction [chloroquine diphosphate inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]PMID:29133031
Afpdecreases expressionISOAfp (Mus musculus)6480464CTDDoxorubicin results in decreased expression of AFP proteinPMID:21251210
Afpdecreases expressionISOAFP (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of AFP mRNAPMID:29803840
Afpmultiple interactionsISOAfp (Mus musculus)6480464CTDsodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of AFP protein]PMID:21251210
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