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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1615538
Species: Mus musculus
RGD Object: Gene
Symbol: Cd59b
Name: CD59b antigen
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd59bincreases response to substanceEXP 6480464CTDCD59 gene mutant form results in increased susceptibility to DoxorubicinPMID:16951374
Cd59baffects expressionISOCD59 (Homo sapiens)6480464CTDDoxorubicin affects the expression of CD59 proteinPMID:29385562
Cd59bdecreases expressionISOCD59 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of CD59 mRNAPMID:29803840
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