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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606587
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP19A1
Name: cytochrome P450 family 19 subfamily A member 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP19A1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of CYP19A1 mRNAPMID:32505695
CYP19A1decreases expressionISOCyp19a1 (Rattus norvegicus)6480464CTDDoxorubicin results in decreased expression of CYP19A1 mRNAPMID:32810592
CYP19A1multiple interactionsISOCyp19a1 (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [Doxorubicin results in decreased expression of CYP19A1 mRNA]; Vitamin E inhibits the reaction [Doxorubicin results in decreased expression of CYP19A1 mRNA]PMID:32810592
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