GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | H2ax | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of H2AX protein; Doxorubicin results in increased expression of H2AX protein modified form | PMID:17875725 PMID:24902966 PMID:29913208 | H2ax | multiple interactions | EXP | | 6480464 | CTD | 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]; [Poly(ADP-ribose) Polymerase Inhibitors co-treated with Doxorubicin] results in increased expression of H2AX protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]; Bortezomib inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]; Quercetin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form]; Razoxane inhibits the reaction [Doxorubicin results in increased expression of H2AX protein] | PMID:17875725 PMID:24902966 PMID:29913208 | H2ax | affects expression | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Doxorubicin affects the expression of H2AX mRNA | PMID:27780733 | H2ax | decreases expression | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of H2AX mRNA | PMID:29803840 PMID:36634904 | H2ax | increases expression | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of H2AX mRNA; Doxorubicin results in increased expression of H2AX protein; Doxorubicin results in increased expression of H2AX protein modified form | PMID:22302033 PMID:30769864 PMID:32107588 PMID:34783124 PMID:35690182 | H2ax | increases expression | ISO | H2ax (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of H2AX protein; Doxorubicin results in increased expression of H2AX protein modified form | PMID:17875725 PMID:28710503 | H2ax | increases phosphorylation | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of H2AX protein | PMID:15489221 PMID:16432175 PMID:20978201 PMID:21356574 PMID:21646468 PMID:22751436 PMID:23899529 PMID:27922187 | H2ax | increases phosphorylation | ISO | H2ax (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of H2AX protein | PMID:22712078 PMID:31368505 | H2ax | multiple interactions | ISO | H2AX (Homo sapiens) | 6480464 | CTD | [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of H2AX mRNA; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein]; CCAR1 protein affects the reaction [Doxorubicin results in increased expression of H2AX protein]; Doxorubicin inhibits the reaction [palbociclib results in decreased phosphorylation of H2AX protein]; Doxorubicin promotes the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of H2AX protein modified form]; Doxorubicin promotes the reaction [CCAR1 protein binds to H2AX protein]; ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of H2AX mRNA]; H2AX protein affects the reaction [Doxorubicin results in increased activity of CASP3 protein]; JNK-IN-8 inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]; myricetin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]; palbociclib inhibits the reaction [Doxorubicin results in increased expression of H2AX protein]; shogaol analog inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein] | PMID:15489221 PMID:22302033 PMID:22751436 PMID:23899529 PMID:27634759 PMID:30769864 PMID:32107588 PMID:34783124 PMID:36634904 | H2ax | multiple interactions | ISO | H2ax (Mus musculus) | 6480464 | CTD | Lovastatin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein]; NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form]; TOP2B protein affects the reaction [Doxorubicin results in increased expression of H2AX protein] | PMID:17875725 PMID:22712078 PMID:28710503 | | ||||||||||||||||||||||
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