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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550849
Species: Mus musculus
RGD Object: Gene
Symbol: Ccna2
Name: cyclin A2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccna2affects expressionISOCCNA2 (Homo sapiens)6480464CTDDoxorubicin affects the expression of CCNA2 proteinPMID:16036217
Ccna2decreases expressionISOCCNA2 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of CCNA2 mRNAPMID:15205334 PMID:29803840 PMID:30031762 PMID:30581319
Ccna2increases expressionISOCCNA2 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of CCNA2; Doxorubicin results in increased expression of CCNA2 proteinPMID:16284694 PMID:22751436
Ccna2multiple interactionsISOCCNA2 (Homo sapiens)6480464CTD[Folic Acid co-treated with Doxorubicin] results in decreased expression of CCNA2 mRNA; Doxorubicin affects the expression of and affects the localization of CCNA2 protein; Doxorubicin promotes the reaction [RBL2 protein binds to CCNA2 promoter]; palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]; RB1 protein affects the reaction [palbociclib inhibits the reaction [Doxorubicin results in increased expression of CCNA2 protein]]PMID:16537896 PMID:17390037 PMID:22751436 PMID:30581319
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