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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550066
Species: Mus musculus
RGD Object: Gene
Symbol: Rfc1
Name: replication factor C (activator 1) 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13534916480464CTDDoxorubicin results in decreased expression of RFC1 mRNA

PMID:29803840
decreases response to substanceISORGD:13534916480464CTDRFC1 protein results in decreased susceptibility to Doxorubicin

PMID:24675091
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.