GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PRKDC | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of PRKDC mRNA | PMID:36634904 | PRKDC | multiple interactions | EXP | | 6480464 | CTD | Doxorubicin promotes the reaction [PRKDC protein results in increased phosphorylation of PRKDC protein]; IC486241 inhibits the reaction [Doxorubicin promotes the reaction [PRKDC protein results in increased phosphorylation of PRKDC protein]]; PRKDC protein affects the reaction [Doxorubicin results in increased activity of CASP3 protein]; PRKDC protein affects the reaction [Doxorubicin results in increased activity of CASP8 protein]; PRKDC protein affects the reaction [Doxorubicin results in increased activity of CASP9 protein] | PMID:18508926 PMID:21567185 | PRKDC | increases expression | ISO | Prkdc (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of PRKDC mRNA | PMID:25896364 | | ||||||||||||||||||||||
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