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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317727
Species: Mus musculus
RGD Object: Gene
Symbol: Arih1
Name: ariadne RBR E3 ubiquitin protein ligase 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arih1increases response to substanceEXP 6480464CTDARIH1 mutant form results in increased susceptibility to DoxorubicinPMID:25624349
Arih1decreases expressionISOARIH1 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of ARIH1 mRNAPMID:29803840
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