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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310885
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Diablo
Name: diablo, IAP-binding mitochondrial protein
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Diabloincreases expressionISODIABLO (Homo sapiens)6480464CTDDoxorubicin results in increased expression of DIABLO mRNAPMID:17521628 PMID:33507000
Diablomultiple interactionsISODIABLO (Homo sapiens)6480464CTD[Doxorubicin co-treated with Melatonin] results in increased expression of DIABLO protein; [Oleanolic Acid results in increased susceptibility to Doxorubicin] which affects the expression of DIABLO mRNA; Doxorubicin promotes the reaction [Melatonin results in increased expression of DIABLO mRNA]PMID:33507000 PMID:37345903
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