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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309728
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cbr3
Name: carbonyl reductase 3
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cbr3affects metabolic processingISOCBR3 (Homo sapiens)6480464CTDCBR3 protein affects the metabolism of Doxorubicin; CBR3 protein alternative form affects the metabolism of DoxorubicinPMID:20007405
Cbr3affects response to substanceISOCBR3 (Homo sapiens)6480464CTDCBR3 gene SNP affects the susceptibility to DoxorubicinPMID:20007405
Cbr3increases metabolic processingISOCbr3 (Mus musculus)6480464CTDCBR3 protein results in increased metabolism of DoxorubicinPMID:25446851
Cbr3multiple interactionsISOCbr3 (Mus musculus)6480464CTD[CBR3 protein results in increased metabolism of Doxorubicin] which results in increased chemical synthesis of adriamycinolPMID:25446851
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