GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akr1b10 | decreases response to substance | ISO | AKR1B10 (Homo sapiens) | 6480464 | CTD | AKR1B10 protein results in decreased susceptibility to Doxorubicin | PMID:25686905 | Akr1b10 | increases expression | ISO | AKR1B10 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of AKR1B10 mRNA | PMID:29803840 | Akr1b10 | multiple interactions | ISO | AKR1B10 (Homo sapiens) | 6480464 | CTD | [AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA; [AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased phosphorylation of MAPK1 protein; [AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased phosphorylation of MAPK3 protein; [AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased expression of MMP2 mRNA]; Oleanolic Acid inhibits the reaction [[AKR1B10 protein results in decreased susceptibility to Doxorubicin] which results in increased secretion of MMP2 protein]; Oleanolic Acid inhibits the reaction [AKR1B10 protein results in decreased susceptibility to Doxorubicin] | PMID:25686905 | | ||||||||||||||||||||||
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