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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11334
Species: Mus musculus
RGD Object: Gene
Symbol: Sp1
Name: trans-acting transcription factor 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp1affects activityISOSP1 (Homo sapiens)6480464CTDDoxorubicin affects the activity of SP1 proteinPMID:17108358
Sp1decreases expressionISOSP1 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of SP1 mRNAPMID:29803840
Sp1increases ribosylationISOSP1 (Homo sapiens)6480464CTDDoxorubicin results in increased ribosylation of SP1 proteinPMID:22293659
Sp1multiple interactionsISOSP1 (Homo sapiens)6480464CTD[Doxorubicin results in increased ribosylation of SP1 protein] affects the reaction [SP1 protein binds to TOP2A promoter]; Doxorubicin promotes the reaction [SP1 protein binds to BIRC5 promoter]; Doxorubicin promotes the reaction [SP1 protein binds to ESR1 promoter]; Doxorubicin promotes the reaction [TP53 protein binds to SP1 protein]PMID:17124180 PMID:19351845 PMID:22293659
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