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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11121
Species: Mus musculus
RGD Object: Gene
Symbol: Plk1
Name: polo like kinase 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plk1decreases expressionISOPLK1 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of PLK1 mRNAPMID:15205334 PMID:30031762
Plk1multiple interactionsISOPLK1 (Homo sapiens)6480464CTDDoxorubicin affects the reaction [[Hydroxyurea co-treated with Nocodazole] affects the expression of and affects the phosphorylation of PLK1 protein]PMID:31597699
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