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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10649
Species: Mus musculus
RGD Object: Gene
Symbol: Gja1
Name: gap junction protein, alpha 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gja1decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of GJA1 mRNAPMID:16243910 PMID:25896364
Gja1decreases expressionISOGja1 (Rattus norvegicus)6480464CTDDoxorubicin results in decreased expression of GJA1 proteinPMID:24291741
Gja1decreases expressionISOGJA1 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of GJA1 mRNAPMID:29803840
Gja1increases expressionISOGja1 (Rattus norvegicus)6480464CTDDoxorubicin results in increased expression of GJA1 proteinPMID:29474904
Gja1multiple interactionsISOGja1 (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [Doxorubicin results in increased expression of GJA1 protein]PMID:29474904
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