Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:692136480464CTDDoxorubicin results in decreased expression of ESR2 mRNA

PMID:23956100
increases expressionISORGD:692136480464CTDDoxorubicin results in increased expression of ESR2 mRNA

PMID:16900372
multiple interactionsISORGD:692136480464CTD[Doxorubicin co-treated with Cyclophosphamide] results in increased expression of ESR2 mRNA, Doxorubicin binds to and results in decreased activity of ESR2 protein

PMID:16322899, PMID:25752796
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.