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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of NQO1 mRNA; Doxorubicin results in decreased expression of NQO1 proteinPMID:29775573 PMID:30734460 PMID:37499777
Nqo1increases expressionEXP 6480464CTDDoxorubicin results in increased expression of NQO1 mRNAPMID:22016648 PMID:25896364
Nqo1multiple interactionsEXP 6480464CTDFNDC5 protein inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; Genistein inhibits the reaction [Doxorubicin results in decreased expression of NQO1 protein]; indole-3-carbinol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 protein]PMID:29775573 PMID:30734460 PMID:37499777
Nqo1affects expressionISONqo1 (Rattus norvegicus)6480464CTDDoxorubicin affects the expression of NQO1 mRNAPMID:12187937
Nqo1decreases expressionISONqo1 (Rattus norvegicus)6480464CTDDoxorubicin results in decreased expression of NQO1 mRNA; Doxorubicin results in decreased expression of NQO1 proteinPMID:22666520 PMID:25169008 PMID:30588110 PMID:30928397 PMID:34343525 PMID:37499777
Nqo1increases expressionISONqo1 (Rattus norvegicus)6480464CTD[Doxorubicin results in increased expression of NFE2L2 protein] which results in increased expression of NQO1 mRNAPMID:24211725
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of NQO1 mRNAPMID:28940058 PMID:29803840 PMID:30031762
Nqo1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTDcelastrol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; celastrol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 protein]; Chitosan analog inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; FNDC5 protein modified form inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; geraniol inhibits the reaction [Doxorubicin results in decreased expression of NQO1 protein]; Metformin inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [FNDC5 protein modified form inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]]PMID:22666520 PMID:30588110 PMID:30928397 PMID:34343525 PMID:37499777
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTD[arsenite results in increased expression of NQO1 protein] which results in decreased susceptibility to DoxorubicinPMID:16494910
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