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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732023
Species: Homo sapiens
RGD Object: Gene
Symbol: MAP2K1
Name: mitogen-activated protein kinase kinase 1
Acc ID: CHEBI:28741
Term: sodium fluoride
Definition: A metal fluoride salt with a Na(+) counterion.
Chemical ID: MESH:D012969
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAP2K1decreases expressionISOMap2k1 (Mus musculus)6480464CTDSodium Fluoride results in decreased expression of MAP2K1 mRNAPMID:27664006
MAP2K1increases phosphorylationISOMap2k1 (Rattus norvegicus)6480464CTDSodium Fluoride results in increased phosphorylation of MAP2K1 proteinPMID:19900517
MAP2K1multiple interactionsISOMap2k1 (Mus musculus)6480464CTDCholine inhibits the reaction [Sodium Fluoride results in decreased expression of MAP2K1 mRNA]PMID:27664006
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